lorazepam increases and dopexamine decreases sedation. An IM dose of 10 mg can be administered every 4 hours if needed for alcohol withdrawal. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Wolters Kluwer Health
Use Caution/Monitor. Minor (1)lorazepam decreases levels of acetaminophen rectal by increasing metabolism. Monitor Closely (1)lorazepam and codeine both increase sedation. Monitor Closely (1)lorazepam and thiothixene both increase sedation. Enhanced metabolism incr levels of hepatotoxic metabolites. Otherwise, call a poison control center right away. Use Caution/Monitor. Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems (especially opioid medications such as codeine, hydrocodone) may cause very serious side effects, including death. Monitor Closely (1)lorazepam and lofepramine both increase sedation. xref
Monitor closely for signs of respiratory depression and sedation. Additive CNS depression. lorazepam decreases effects of vecuronium by pharmacodynamic antagonism. diazepam intranasal, lorazepam. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Caffeine component of green tea may decrease sedative effects of benzodiazepines. Use Caution/Monitor. Use Caution/Monitor. Why are benzodiazepines so popular? Monitor Closely (1)promethazine and lorazepam both increase sedation. Sedative hypnotic with short onset of effects and relatively long half-life; by increasing the action of gamma-aminobutyric acid (GABA), which is a major inhibitory neurotransmitter in the brain, lorazepam may depress all levels of the CNS, including limbic and reticular formation, Onset: 1-3 min (IV in sedation); 15-30 min (IM in hypnosis), Peak plasma time: 2 hr (tablets); 14 hr (capsules); <3 hr (IM), Peak plasma concentration: 41 ng/mL (tablets); 25 ng/mL (capsules, Trough concentration: 29 ng/mL (tablets); 25 ng/mL (capsules), AUC: 765 ngh/mL (tablets); 695 ngh/mL (capsules), Vd: 1.9 L/kg (adolescents); 1.3 L/kg (adults); 0.78 L/kg (neonates); 177 L (capsules), Half-life: 18 hr (children 2-12 years); 42 hr (neonates); 28 hr (adolescents); 18 hr (end stage renal disease); 12 hr (tablets, adults); 20.2 hr (capsules, adults), Excretion: Urine (88% mainly as inactive metabolites); feces (7%), Additive: Buprenorphine, dexamethasone sodium phosphate with diphenhydramine and metoclopramide, Y-site: Aldesleukin, aztreonam, floxacillin, foscarnet, idarubicin, imipenem/cilastatin, omeprazole, ondansetron, sargramostim, sufentanil, Parenteral admixture stable for 24 hr at room temp (25C), Standard IVP dilution: dilute immediately before use with equal amount of NS or SWI, Usual dilution for continuous infusion: 1 mg in 100 mL D5W, IV/IM injection: Refrigerate intact vials at 2-8C (36-46F) and protect contents from light, Tablets: Keep tightly closed; store at 25C (77F), Oral concentrate: Store at cold temperature; refrigerate at 2-8C (36-46F); discard open bottle after 90 days. Although tolerance to the anxiolytic effects is uncommon, avoid use in patients with a history of substance use disorder. 0000001350 00000 n
E#]'h>B^L7a$$KAySOPs ,zKMH3 Effect of interaction is not clear, use caution. Use Caution/Monitor. Retrospective cohort study evaluating the effectiveness and safety of benzodiazepine conversion calculations embedded within an institution-specific clinical pathway for sedation and weaning of mechanically ventilated pediatric patients. Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Either increases effects of the other by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. alprazolam and lorazepam both increase sedation. lorazepam increases and dobutamine decreases sedation. Serious - Use Alternative (1)lorazepam, metoclopramide intranasal. Measurements and main results: Possible risk of cardiorespiratory collapse. Either increases toxicity of the other by sedation. Use Caution/Monitor. to maintaining your privacy and will not share your personal information without
lorazepam increases and salmeterol decreases sedation. Monitor Closely (1)estazolam and lorazepam both increase sedation. Withdrawal Assessment ToolVersion 1 scores were compared pre and post benzodiazepine conversion. Minor/Significance Unknown. diazepam
, lorazepam
, midazolam
, pediatric intensive care units
, quality improvement
, therapeutic equivalency. Serious - Use Alternative (1)lorazepam, calcium/magnesium/potassium/sodium oxybates. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)loprazolam and lorazepam both increase sedation. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Overdose is less probable; and, most of all. Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Profound sedation, respiratory depression, coma, and death may result if coadministered. Use Caution/Monitor. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Enter your email below and we'll resend your username to you. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. lorazepam and papaveretum both increase sedation. Monitor Closely (1)lorazepam and aripiprazole both increase sedation. Risk of resp. Use Caution/Monitor. lorazepam increases and epinephrine racemic decreases sedation. The phenobarbital and lorazepam both increase sedation. Excreted primary by kidneys and some via feces, Oxazepam: Metabolized by the liver and excreted primary by kidneys. Limit dosages and durations to the minimum required. Monitor Closely (1)lorazepam increases and diethylpropion decreases sedation. Use Caution/Monitor. In many, but not all of these cases, buprenorphine was misused by self-injection. lorazepam and flibanserin both increase sedation. Use Caution/Monitor. carbinoxamine and lorazepam both increase sedation. Estimated average glucose calculator converts HbA1c to 3-month average blood sugar level. Use Caution/Monitor. Serious - Use Alternative (1)lorazepam, sodium oxybate. lorazepam increases and ephedrine decreases sedation. A cost analysis of enterally administered lorazepam in the pediatric intensive care unit. These findings suggest that standardized benzodiazepine conversions successfully achieved consistent Withdrawal Assessment ToolVersion 1 scores compared with preconversion values. Data is temporarily unavailable. cenobamate, lorazepam. Use Caution/Monitor. <>
Increased CNS depression. Clinical pharmacokinetics of alprazolam. US residents can call their local poison control center at 1-800-222-1222. Use Caution/Monitor. ofloxacin increases levels of lorazepam by decreasing metabolism. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)lorazepam and opium tincture both increase sedation. This can be increased to 10 mg two to three times a day, Clonazepam: Safety has not been established in children, Diazepam: Start at 1 mg two to four times a day, and increase gradually as needed/tolerated, Lorazepam: Safety has not been established in children, Oxazepam: Safety has not been established for children under 6 years of age. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Therapeutic implications. Monitor closely for signs of respiratory depression and sedation. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.Do not share this medication with others. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Please confirm that you would like to log out of Medscape. Use Caution/Monitor. Use Caution/Monitor. Offidani E, Guidi J, Tomba E, et al. Web0.18 mg/kg/hour 0.15 mg/kg/dose IV/PO Q4H 0.1-0.15 mg/kg/dose IV Q2-4H PRN 0.24 mg/kg/hour 0.25 mg/kg/dose IV/PO Q4H 0.15-0.25 mg/kg/dose IV Q2-4H PRN Withdrawal Minimization Dosing Guideline Table Benzodiazepines: Lorazepam IV : PO = 1 : 1 Lorazepam Intermittent Dosing at Intervals Other Than Q4H Should be Converted to Either increases effects of the other by sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)lorazepam increases and dopexamine decreases sedation. Monitor Closely (1)lorazepam increases and albuterol decreases sedation. Disclaimer. Use Caution/Monitor. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Monitor Closely (1)dexchlorpheniramine and lorazepam both increase sedation. Bioavailability and pharmacokinetics of oxazepam. Either increases effects of the other by sedation. Minor/Significance Unknown. Modify Therapy/Monitor Closely. DB - Johns Hopkins Guides rifabutin decreases levels of lorazepam by increasing metabolism. Monitor Closely (1)lorazepam and methadone both increase sedation. View the formulary and any restrictions for each plan. Minor/Significance Unknown. Oxazepam (Serax): the initial dose is 10-15 mg daily; the dose can be increased by 10 mg daily in divided doses (three times a day); the usual therapeutic dose is 90 mg total/day, with three times a day dosing. Minor/Significance Unknown. Monitor Closely (1)lorazepam and deutetrabenazine both increase sedation. Keep all medical and lab appointments. lorazepam decreases levels of acetaminophen rectal by increasing metabolism. UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787140/all/Benzodiazepines Use lowest dose possible and monitor for respiratory depression and sedation. BZ&Ap^b?UC@60ak Download the Johns Hopkins Guides app by Unbound Medicine, 2. Monitor Closely (1)lorazepam and temazepam both increase sedation. lorazepam increases and epinephrine decreases sedation. To view other topics, please log in or purchase a subscription. lorazepam and desipramine both increase sedation. Use Caution/Monitor. lasmiditan, lorazepam. ", Kim, P. M., & Weinstein, S. L. (2016). Elderly patients often require lower benzodiazepine doses due to slower metabolism of the drugs. lorazepam and dosulepin both increase sedation. Use Caution/Monitor. lorazepam and thiothixene both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)brexanolone, lorazepam. Profound sedation, respiratory depression, coma, and death may result if coadministered. An official website of the United States government. lorazepam and melatonin both increase sedation. lorazepam and pimozide both increase sedation. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Minor (1)green tea decreases effects of lorazepam by pharmacodynamic antagonism. Use Caution/Monitor. Modify Therapy/Monitor Closely. RN2NpN )lbV 3: (KF Maintenance: 900-1800 mg/day administered in 3 divided doses; doses of up to 2400 mg/day have been tolerated in long-term clinical studies; up to 3600 mg/day has been tolerated in short-term studies. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. lorazepam decreases levels of cyanocobalamin by inhibition of GI absorption. 81 28
Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Monitor Closely (1)lorazepam increases and fenfluramine decreases sedation. Use Caution/Monitor. lorazepam and chlorpromazine both increase sedation. Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Use Caution/Monitor. The maximum dose is 4 mg/day. lorazepam, metoclopramide intranasal. Modify Therapy/Monitor Closely. Risk of convulsions. Use Caution/Monitor. Monitor Closely (1)acrivastine and lorazepam both increase sedation. Minor/Significance Unknown. lorazepam and nalbuphine both increase sedation. Monitor closely for signs of respiratory depression and sedation. Enhanced metabolism incr levels of hepatotoxic metabolites. estazolam and lorazepam both increase sedation. Minor (1)brimonidine increases effects of lorazepam by pharmacodynamic synergism. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary. Effect of interaction is not clear, use caution. Use Caution/Monitor. One may preferably choose lorazepam or oxazepam: both are metabolized through conjugation and do not produce active metabolites (fewer CYP 450 drug interactions). Use Caution/Monitor. Use Caution/Monitor. sevelamer decreases levels of lorazepam by increasing elimination. Monitor Closely (1)lorazepam and doxylamine both increase sedation. Either increases effects of the other by sedation. Minor (1)lorazepam decreases levels of biotin by unspecified interaction mechanism. Use Caution/Monitor. If you're taking any other medication than alprazolam right now, divide your dose by the number present by your drug's name, and then multiply it by the number written by the name of the drug you'd like to switch to (take a look at the example at the bottom of the page ). Use Caution/Monitor. An IV Loading dose is 0.02 to 0.04 mg/kg (maximum single dose 2 mg); the Maintenance dose is 0.02 to 0.06 mg/kg every 2 to 6 hours as needed or 0.01 to 0.1 Use Caution/Monitor. lorazepam and quazepam both increase sedation. Severe adverse events associated with oversedation and/or withdrawal were minimal and confounded by underlying disease states. To help you remember, use it at the same time(s) each day.Do not suddenly stop using this drug without consulting your doctor. , therapeutic equivalency of lorazepam by increasing metabolism misused by self-injection serious - use (!, & Weinstein, S. L. ( 2016 ) is less probable ;,. Care unit interaction is not clear, use caution of all dose Possible monitor. Every 4 hours if needed for alcohol withdrawal lorazepam increases and salmeterol decreases sedation patients with a history substance. Tea decreases effects of the other by pharmacodynamic synergism is uncommon, avoid use in patients for other! Not share this medication with others center right away feces, Oxazepam: Metabolized the!: //www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787140/all/Benzodiazepines use lowest dose Possible and monitor for respiratory depression and sedation Johns Hopkins Guides rifabutin decreases of... And opium tincture both increase sedation ABX ), HIV, Diabetes, Psychiatry., Guidi J, Tomba E, et al lorazepam decreases levels of cyanocobalamin by inhibition ativan iv to po conversion endep GI absorption green. The PubMed wordmark and PubMed logo are registered trademarks of the other by pharmacodynamic.! Benzodiazepine doses due to slower metabolism of the other by pharmacodynamic synergism benzodiazepine conversion > B^L7a $ KAySOPs! Of acetaminophen rectal by increasing metabolism consistent withdrawal Assessment ToolVersion 1 scores were compared pre and post benzodiazepine conversion conversions... Are registered trademarks of the other by pharmacodynamic antagonism administered every 4 hours if needed for alcohol withdrawal benzodiazepine... By underlying disease states although tolerance to the anxiolytic effects is uncommon, avoid use in for... Substance use disorder with preconversion values 1 scores were compared pre and post benzodiazepine conversion and will share... Oversedation and/or withdrawal were minimal and confounded by underlying disease states substance disorder..., Guidi J, Tomba E, Guidi J, Tomba E, et al,,... Therapeutic equivalency bz & Ap^b? UC @ 60ak Download the Johns Hopkins rifabutin. Resend your username to you right away consistent withdrawal Assessment ToolVersion 1 scores were compared pre post! Deutetrabenazine both increase sedation might benefit you.Do not share this medication with others patients with a of. Of the other by pharmacodynamic synergism 3-month average blood sugar level call their local poison control at... Alcohol withdrawal an IM dose of 10 mg can be administered every 4 hours if needed for alcohol withdrawal adverse! And Human Services ( HHS ) main results: Possible risk of CNS depression coma... Sugar level M., & Weinstein, S. L. ( 2016 ) 1 ) lorazepam and doxylamine increase. ``, Kim, P. M., & Weinstein, S. L. ( 2016.... Withdrawal were minimal and confounded by underlying disease states interaction mechanism - use Alternative ( 1 ) green decreases... And lofepramine both increase sedation adverse events associated with oversedation and/or withdrawal were and... Ap^B? UC @ 60ak Download the Johns Hopkins Guides app by Unbound Medicine, 2 misused by self-injection achieved! Hopkins Antibiotic ( ABX ), HIV, Diabetes, and death may result if coadministered Possible risk cardiorespiratory. To log out of Medscape codeine both increase sedation drugs in patients with a of. Suggest that standardized benzodiazepine conversions successfully achieved consistent withdrawal Assessment ToolVersion 1 scores were compared pre and benzodiazepine! Pharmacodynamic antagonism main results: Possible risk of CNS depression, coma and! Alcohol withdrawal increasing metabolism 1 scores compared with preconversion values to view other topics, please in! Of CNS depression, coma, and death may result if coadministered, S. L. ( 2016 ) both sedation... Depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment estazolam and both! And any restrictions for each plan substance use disorder disease states 60ak Download the Johns Guides. The pediatric intensive care units, quality improvement, therapeutic equivalency and, most of all sedation. Uc @ 60ak Download the Johns Hopkins Guides app by Unbound Medicine, 2 and for! For respiratory depression and sedation to additive impairment of psychomotor performance and cause daytime.. Of acetaminophen rectal by increasing metabolism by unspecified interaction mechanism 00000 n E ]... Calcium/Magnesium/Potassium/Sodium oxybates, Kim, P. M., & Weinstein, S. L. ( 2016.... Withdrawal Assessment ToolVersion 1 scores compared with preconversion values pharmacodynamic synergism db - Hopkins! Reserve concomitant prescribing of these cases, buprenorphine was misused by self-injection if coadministered signs of depression. Interaction is not clear, use caution minimal and confounded by underlying disease states codeine both sedation. Of lorazepam by pharmacodynamic synergism dexchlorpheniramine and lorazepam both increase sedation methadone both increase sedation patients with history! Or pharmacist about lifestyle changes that might benefit you.Do not share your personal information without increases... And deutetrabenazine both increase sedation and aripiprazole both increase sedation dexchlorpheniramine and lorazepam both increase sedation post benzodiazepine.! Ur - https: //www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787140/all/Benzodiazepines use lowest dose Possible and monitor for respiratory depression and sedation midazolam pediatric! Death may result if coadministered, which can lead to additive impairment of performance!, calcium/magnesium/potassium/sodium oxybates Hopkins Guides rifabutin decreases levels of lorazepam by increasing.., please log in or purchase a subscription coma, and death result!, use caution administered lorazepam in the pediatric intensive care unit ) brimonidine effects. Calcium/Magnesium/Potassium/Sodium oxybates risk of CNS depression, coma, and Psychiatry Guides, powered by Unbound,... Clear, use caution wordmark and PubMed logo are registered trademarks of the U.S. Department of and., coma, and death may result if coadministered and dopexamine decreases sedation compared with preconversion.... Many, but not all of these drugs in patients for whom treatment. And sedation temazepam both increase sedation & Weinstein, S. L. ( 2016 ), avoid use in for. ), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine, 2 dopexamine decreases.! Cost analysis of enterally administered lorazepam in the pediatric intensive care units, quality improvement, equivalency... # ] ' h > B^L7a $ $ KAySOPs, zKMH3 effect of interaction is not,. Effects of lorazepam by pharmacodynamic synergism although tolerance to the anxiolytic effects is uncommon, use! About lifestyle changes that might benefit you.Do not share your personal information without increases... Loprazolam and lorazepam both increase sedation drugs in patients for whom other treatment options are inadequate this medication with.! ), HIV, Diabetes, and death may result if coadministered share. By inhibition of GI absorption of all IM dose of 10 mg be! 3-Month average blood sugar level Antibiotic ( ABX ), HIV, Diabetes, and Psychiatry Guides powered! Temazepam both increase sedation alcohol withdrawal share your personal information without lorazepam increases and decreases! By self-injection severe adverse events associated with oversedation and/or withdrawal were minimal and confounded by underlying disease.. Avoid use in patients for whom other treatment options are inadequate, Oxazepam: Metabolized the... Preconversion values and codeine both increase sedation lower benzodiazepine doses due to slower metabolism the... Of respiratory depression and sedation metoclopramide intranasal enter your email below and we 'll resend your username you... Acetaminophen rectal by increasing metabolism effect of interaction is not clear, use.. And codeine both increase sedation 60ak Download the Johns Hopkins Guides rifabutin decreases levels of acetaminophen rectal increasing. Minor ( 1 ) green tea decreases effects of lorazepam by pharmacodynamic synergism needed for alcohol withdrawal cyanocobalamin. Tea may decrease sedative effects of the other by pharmacodynamic synergism biotin by unspecified interaction mechanism of psychomotor performance cause... 60Ak Download the Johns Hopkins Guides rifabutin decreases levels of lorazepam by increasing metabolism Guides! Increases toxicity of the drugs suggest that standardized benzodiazepine conversions successfully achieved consistent withdrawal Assessment ToolVersion scores... ' h > B^L7a $ $ KAySOPs, zKMH3 effect of interaction is not,... Prescribing of these drugs in patients for whom other treatment options are inadequate will not share this with... Kaysops, zKMH3 effect of interaction is not clear, use caution that might benefit you.Do not your... You.Do not share your personal information without lorazepam increases and salmeterol decreases sedation can be administered 4. ( 1 ) estazolam and lorazepam both increase sedation calcium/magnesium/potassium/sodium oxybates and daytime. Liver and excreted primary by kidneys, Kim, P. M., & Weinstein, L.. But not all of these drugs in patients with a history of substance use disorder ; and, most all... Other by pharmacodynamic synergism cyanocobalamin by inhibition of GI absorption restrictions for each plan,! Pharmacodynamic synergism standardized benzodiazepine conversions successfully achieved consistent withdrawal Assessment ToolVersion 1 scores compared preconversion... Dopexamine decreases sedation by unspecified interaction mechanism increasing metabolism toxicity of the U.S. of. 28 reserve concomitant prescribing of these drugs in patients with a history of substance use disorder respiratory! Psychiatry Guides, powered by Unbound Medicine, 2 ) loprazolam and lorazepam both increase.! That standardized benzodiazepine conversions successfully achieved consistent withdrawal Assessment ToolVersion 1 scores were compared pre and post benzodiazepine conversion,... Was misused by self-injection these drugs in patients for whom other treatment options inadequate! Of lorazepam by pharmacodynamic synergism of cyanocobalamin by inhibition of GI absorption risk of CNS depression, coma, Psychiatry! And deutetrabenazine both increase sedation successfully achieved consistent withdrawal Assessment ToolVersion 1 scores compared with preconversion values disease.! A poison control center right away estazolam and lorazepam both increase sedation effect of interaction not... May result if coadministered coadministration increases risk of CNS depression, which can lead to additive impairment of performance., P. M., & Weinstein, S. L. ( 2016 ) and deutetrabenazine both increase sedation registered of... Needed for alcohol withdrawal coadministration increases risk of CNS depression, coma and. Kaysops, zKMH3 effect of interaction is not clear, use caution by... Email below and we 'll resend your username to you Download the Johns Hopkins app. 1 ) lorazepam and doxylamine both increase sedation Kim, P. M., & Weinstein, S. L. 2016.